Orion — the Hunter
The giant huntsman of Boeotia made one boast too many: he would slay every animal on Earth. Gaia, the Earth herself, answered by sending the smallest of assassins — a scorpion — which stung his heel and killed him.
The gods placed both in the sky, but opposite each other: as Scorpius rises in the east, Orion flees below the western horizon, and only returns when the scorpion has set. The feud is built into the clockwork of the sky — the reason Orion rules winter evenings and Scorpius rules summer.